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Exposure to benzene has been associated with certain types of leukemia, as well as certain blood disorders.

Occupational exposures to benzene account for the greatest amount of high-level exposures. The Occupational Safety and Health Administration (OSHA) has regulations pertaining to what constitutes permissible exposure limits for benzene. The National Institute for Occupational Safety and Health (NIOSH) recommends that benzene be controlled and handled as a potential human carcinogen in the work place and that exposure be reduced to the lowest feasible limit.

Benzene-related blood disorders began receiving attention in publications as early as 1897. Benzene has been used as a raw material in the synthesis of compounds such as styrene, phenol and cyclohexane. Benzene is widely known in the medical community to cause AML (Acute Myelogenous Leukemia).

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